MrBeast is known for his videos of stunts, pranks and extravagant giveaways, but the YouTuber has also gained attention for speaking out about his lifelong disease.
The 24-year-old, who has more than 130 million subscribers on YouTube, made headlines recently for using his wealth to help support other people suffering from health issues as he sponsored cataract surgeries to help 1,000 blind people see again.
As if the gift of sight wasn't enough, MrBeast also handed out prizes to participants of the venture, including briefcases which he said contained $10,000 (£8,100) each.
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After the YouTuber, whose real name is Jimmy Donaldson, shared a video of his efforts to help restore people's sight, one fan responded to encourage him to now use his money to fund research into the disease he suffers from himself.
They wrote: "You should look into a cure for Crohns. Partner suffers so bad from it for the last 12 years. I know you to suffer with it."
MrBeast has indeed previously revealed that he's been diagnosed with Crohn's disease; a currently incurable disease in which parts of the digestive system become inflamed.
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Crohn's is believed to affect 10 million people globally, with main treatments including medicines to reduce and prevent inflammation, and surgery to remove a small part of the digestive system.
MrBeast was diagnosed with the disease when he was in the ninth grade at school, after experiencing extreme pain and sickness.
In 2015, the YouTuber released a video discussing the condition in which he said it 'isn't the worst thing ever', adding: "There's people who have way worse diseases...
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"There are worse things than Crohn's out there, which is sometimes why I'm a little bit hesitant to talk about it or complain about it."
To help cope with his Crohn's, MrBeast described eating 'certain foods every single week of every single year'.
"It gets really repetitive, but you have to eat those certain foods so your stomach doesn't get all messed up and you're not in constant pain 24/7," he said. "It's a small, strict diet — or at least mine is. It's different for everyone."
The YouTuber went on to explain how it affects his social life, noting that hanging out with friends can be hard when it 'revolves around food'.
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“Sometimes, I end up bringing my own PB&J when we’re eating fast food or things like that. It just sucks all the fun out of food. I mean, eating food is a huge part of your life," he said.
Symptoms of Crohn's disease include diarrhoea, stomach aches, blood in your poo, tiredness and weight loss.